CorneaMD

CorneaMD: A Multiomics Database for Corneal Diseases

Species
Human
Rabbit
Mouse
Danio rerio

Sources
Corneal endothelium
Central cornea
Corneal epithelium
Whole cornea
Limbal stem cells
Limbus
hiPSC-derived limbal epithelial progenitor cells
Sclera
Corneal stroma
Trigeminal ganglia
Corneal grafts
hESC-derived corneal endothelial cells
Corneal endothelial cells
Mesenchyaml stromal cells
Mesenchymal stromal cells
Tissue-engineered human cornea
Cornea epithelial and stromal cells
Corneal epithelial cells

Conditions
Fuchs' endothelial corneal dystrophy
Keratoconus
Wound healing
Dry eye
Cultured cell lines
SARS-CoV-2 infection
Diabetic keratopathy
Corneal transplantation
Development
Alkali burn
Infectious keratitis
Normal tissue
Bioengineered cornea
Corneal preservation

Technology
Total RNA-seq
mRNA-seq
miRNA-seq
MicroArray

Datasets	Species	Sources	Conditions	Technology	Sample number	Publications
GSE142538	Human	Corneal endothelium	Fuchs' endothelial corneal dystrophy	Total RNA-seq	25	Analyzing pre-symptomatic tissue to gain insights into the molecular and mechanistic origins of late-onset degenerative trinucleotide repeat disease Chu Y et al. Nucleic Acids Res. 2020.
GSE151631	Human	Central cornea	Keratoconus	Total RNA-seq	26	RNA sequencing of corneas from two keratoconus patient groups identifies potential biomarkers and decreased NRF2-antioxidant responses Vishal S et al. Sci. Rep. 2020.
GSE112155	Human	Corneal epithelium	Keratoconus	Total RNA-seq	20	RNA-Seq analysis and comparison of corneal epithelium in keratoconus and myopia patients You J et al. Sci Rep. 2018.
GSE77938	Human	Whole cornea	Keratoconus	Total RNA-seq	50	Collagen synthesis disruption and downregulation of core elements of TGF-β, Hippo, and Wnt pathways in keratoconus corneas Kabza M et al. Eur J Hum Genet. 2017.
GSE156271	Human	Limbal stem cells	Wound healing	Total RNA-seq	12	Core transcription regulatory circuitry orchestrates corneal epithelial homeostasis Li M et al. Nat Commun. 2021.
GSE180698	Human	Limbus	Wound healing	Total RNA-seq	6	WNT16B enhances the proliferation and self-renewal of limbal epithelial cells via CXCR4/MEK/ERK signaling Zhao S et al. Stem Cell Reports. 2022.
PRJNA480359	Rabbit	Limbus	Wound healing	Total RNA-seq	9	Fibronectin regulates the self-renewal of rabbit limbal epithelial stem cells by stimulating the Wnt11/Fzd7/ROCK non-canonical Wnt pathway Zheng M et al. Exp Eye Res. 2019.
GSE208297	Mouse	Whole cornea	Dry eye	Total RNA-seq	19	A synthetic tear protein resolves dry eye through promoting corneal nerve regeneration Efraim Y et al. Cell Rep. 2022.
GSE191228	Mouse	Whole cornea	Wound healing	Total RNA-seq	6	dsRNA induced IFNβ-MMP13 axis drives corneal wound healing Lan X et al. Invest Ophthalmol Vis Sci. 2022.
GSE193784	Danio rerio	Whole cornea	Wound healing	Total RNA-seq	8	Unilateral zebrafish corneal injury induces bilateral cell plasticity supporting wound closure Ikkala K et al. Sci Rep. 2022.
PRJNA875057	Human	hiPSC-derived limbal epithelial progenitor cells	Cultured cell lines	Total RNA-seq	11	Transcriptomic landscape and functional characterization of human induced pluripotent stem cell-derived limbal epithelial progenitor cells Polisetti N et al. Cells. 2022.
GSE164073	Human	Central cornea	SARS-CoV-2 infection	Total RNA-seq	6	SARS-CoV-2 infects human adult donor eyes and hESC-derived ocular epithelium Eriksen AZ et al. Cell Stem Cell. 2021.

Previous
1
2
3
4
Next