CorneaMD

CorneaMD: A Multiomics Database for Corneal Diseases

Species
Human
Mouse
Macaca mulatta

Sources
Corneal epithelium
Corneal stroma
Whole cornea
Tear
Aqueous humor
Limbal epithelial cells
Corneal endothelium

Conditions
Keratoconus
Diabetic keratopathy
MiR-146a treatment
Alkali burn
Corneal endothelial cell dysfunction
Myopia
Corneal transplantation

Technology
LFQ-DIA
TMT-DDA
LFQ-DDA
Dimethyl labeling-DDA

Datasets	Species	Sources	Conditions	Technology	Sample number	Publications
PMC6393548	Human	Corneal epithelium	Keratoconus	LFQ-DIA	10	Differential epithelial and stromal protein profiles in cone and non-cone regions of keratoconus corneas Yam GH et al. Sci Rep. 2019.
PMC6393548	Human	Corneal stroma	Keratoconus	LFQ-DIA	10	Differential epithelial and stromal protein profiles in cone and non-cone regions of keratoconus corneas Yam GH et al. Sci Rep. 2019.
PMC6857467	Human	Whole cornea	Keratoconus	TMT-DDA	10	Mapping keratoconus molecular substrates by multiplexed high-resolution proteomics of unpooled corneas Shinde V et al. OMICS. 2019.
PMC8399462	Human	Tear	Keratoconus	LFQ-DIA	50	Tear proteomics in keratoconus: a quantitative SWATH-MS analysis López-López M et al. Invest Ophthalmol Vis Sci. 2021.
PMC4415580	Human	Aqueous humor	Keratoconus	LFQ-DDA	10	Label-free LC-MS/MS quantitative analysis of aqueous humor from keratoconic and normal eyes Soria J et al. Mol Vis. 2015.
PMC6274742	Mouse	Whole cornea	Diabetic keratopathy	LFQ-DDA	5	A proteomic approach for understanding the mechanisms of delayed corneal wound healing in diabetic keratopathy using diabetic model rat Yamamoto T et al. Int J Mol Sci. 2018.
PMC7650592	Human	Limbal epithelial cells	MiR-146a treatment	TMT-DDA	4	Integrated transcriptome and proteome analyses reveal the regulatory role of miR-146a in human limbal epithelium via notch signaling Poe AJ et al. Cells. 2020.
PMC7427785	Human	Corneal endothelium	Diabetic keratopathy	LFQ-DDA	19	Proteomic analysis of corneal endothelial cell-descemet membrane tissues reveals influence of insulin dependence and disease severity in type 2 diabetes mellitus Skeie JM et al. PLoS One. 2018.
PMC10777872	Mouse	Whole cornea	Alkali burn	LFQ-DDA	18	Exploring corneal neovascularization: an integrated approach using transcriptomics and proteomics in an alkali burn mouse model Wang W et al. Invest Ophthalmol Vis Sci. 2024.
PMC10607268	Human	Aqueous humor	Corneal endothelial cell dysfunction	LFQ-DIA	10	Integrated analysis of transcriptome and proteome of the human cornea and aqueous humor reveal novel biomarkers for corneal endothelial cell dysfunction Moon CE et al. Int J Mol Sci. 2023.
PMC10607268	Human	Aqueous humor	Corneal endothelial cell dysfunction	LFQ-DIA	14	Integrated analysis of transcriptome and proteome of the human cornea and aqueous humor reveal novel biomarkers for corneal endothelial cell dysfunction Moon CE et al. Int J Mol Sci. 2023.
PMID37389637	Human	Corneal stroma	Myopia	TMT-DDA	18	Comparisons of the protein expressions between high myopia and moderate myopia on the anterior corneal stroma in human Wu W et al. Graefes Arch Clin Exp Ophthalmol. 2023.