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CorneaMD: A Multiomics Database for Corneal Diseases

Species
Human
Mouse
Macaca fascicularis
Sources
hESC-derived SEAM
Limbus
Limbal epithelium
Limbal stem cells
Whole cornea
Corneal epithelium
Central cornea
Corneal endothelium
hiPSC-derived corneal organoid
Corneal immune cells
hiPSC-derived SEAM
Conditions
Organoid
Normal tissue
Development_10pcw
Development_12pcw
Development_14pcw
Development_16pcw
Development_17pcw
Development_20pcw
Development_Adult
Beclin1-deficient mouse
Keratoconus
Aging
Diabetic keratopathy
Dry eye
Development
Wound healing
Cataract
Technology
scRNA-seq
snRNA-seq
Datasets Species Sources Conditions Technology Cell number Publications
GSE165477 Human hESC-derived SEAM Organoid scRNA-seq 10821
SARS-CoV-2 infects human adult donor eyes and hESC-derived ocular epithelium
Eriksen AZ et al. Cell Stem Cell. 2021.
GSE157474 Human Limbus Normal tissue scRNA-seq 47627
Molecular identity of human limbal heterogeneity involved in corneal homeostasis and privilege
Dou S et al. Ocul Surf. 2021.
GSE157474 Human Limbal epithelium Normal tissue scRNA-seq 26099
Molecular identity of human limbal heterogeneity involved in corneal homeostasis and privilege
Dou S et al. Ocul Surf. 2021.
GSE153515 Human Limbal epithelium Normal tissue scRNA-seq 15846
Single-cell transcriptomics identifies limbal stem cell population and cell types mapping its differentiation trajectory in limbal basal epithelium of human cornea
Li D et al. Ocul Surf. 2021.
GSE156524 Human Limbal stem cells Normal tissue scRNA-seq 3749
Limbal BCAM expression identifies a proliferative progenitor population capable of holoclone formation and corneal differentiation
Sasamoto Y et al. Sci Rep. 2022.
GSE186433 Human Whole cornea Normal tissue scRNA-seq 19472
Single cell transcriptomics reveals the heterogeneity of the human cornea to identify novel markers of the limbus and stroma
Català P et al. Sci Rep. 2021.
GSE155683 Human Whole cornea Development_10pcw scRNA-seq 1149
A single cell atlas of human cornea that defines its development, limbal progenitor cells and their interactions with the immune cells
Collin J et al. Ocul Surf. 2021.
GSE155683 Human Whole cornea Development_12pcw scRNA-seq 21002
A single cell atlas of human cornea that defines its development, limbal progenitor cells and their interactions with the immune cells
Collin J et al. Ocul Surf. 2021.
GSE155683 Human Whole cornea Development_14pcw scRNA-seq 22057
A single cell atlas of human cornea that defines its development, limbal progenitor cells and their interactions with the immune cells
Collin J et al. Ocul Surf. 2021.
GSE155683 Human Whole cornea Development_16pcw scRNA-seq 12770
A single cell atlas of human cornea that defines its development, limbal progenitor cells and their interactions with the immune cells
Collin J et al. Ocul Surf. 2021.
GSE155683 Human Whole cornea Development_17pcw scRNA-seq 9501
A single cell atlas of human cornea that defines its development, limbal progenitor cells and their interactions with the immune cells
Collin J et al. Ocul Surf. 2021.
GSE155683 Human Whole cornea Development_20pcw scRNA-seq 23364
A single cell atlas of human cornea that defines its development, limbal progenitor cells and their interactions with the immune cells
Collin J et al. Ocul Surf. 2021.