Analyzing pre-symptomatic tissue to gain insights into the molecular and mechanistic origins of late-onset degenerative trinucleotide repeat disease
Species
Human
Source
Corneal endothelium
Condition
Fuchs' endothelial corneal dystrophy
Technology
Total RNA-seq
Groups
Control (healthy sample, n = 9); Pre_S (pre-symptomatic sample, n = 6); FECD_NR (advanced FECD without the expanded CTG repeat, n = 4); FECD_REP (patients with late stage FECD, n = 6)
Citation
Chu, Yongjun et al. "Analyzing pre-symptomatic tissue to gain insights into the molecular and mechanistic origins of late-onset degenerative trinucleotide repeat disease." Nucleic acids research vol. 48,12 (2020): 6740-6758. doi:10.1093/nar/gkaa422
