CorneaMD

CorneaMD: A Multiomics Database for Corneal Diseases

Species
Human
Mouse
Macaca fascicularis

Sources
hESC-derived SEAM
Limbus
Limbal epithelium
Limbal stem cells
Whole cornea
Corneal epithelium
Central cornea
Corneal endothelium
hiPSC-derived corneal organoid
Corneal immune cells
hiPSC-derived SEAM

Conditions
Organoid
Normal tissue
Development_10pcw
Development_12pcw
Development_14pcw
Development_16pcw
Development_17pcw
Development_20pcw
Development_Adult
Beclin1-deficient mouse
Keratoconus
Aging
Diabetic keratopathy
Dry eye
Development
Wound healing
Cataract

Technology
scRNA-seq
snRNA-seq

Datasets	Species	Sources	Conditions	Technology	Cell number	Publications
HRA000781	Human	Corneal endothelium	Normal tissue	scRNA-seq	16946	Heterogeneity of human corneal endothelium implicates lncRNA NEAT1 in Fuchs endothelial corneal dystrophy Wang Q et al. Mol Ther Nucleic Acids. 2022.
GSE182583	Mouse	Corneal epithelium	Normal tissue	scRNA-seq	38111	Dry eye disease in mice activates adaptive corneal epithelial regeneration distinct from constitutive renewal in homeostasis Lin JB et al. Proc Natl Acad Sci U S A. 2023.
GSE182419	Mouse	Corneal epithelium	Aging	scRNA-seq	21669	Dry eye disease in mice activates adaptive corneal epithelial regeneration distinct from constitutive renewal in homeostasis Lin JB et al. Proc Natl Acad Sci U S A. 2023.
GSE182477	Mouse	Corneal epithelium	Diabetic keratopathy	scRNA-seq	17808	Dry eye disease in mice activates adaptive corneal epithelial regeneration distinct from constitutive renewal in homeostasis Lin JB et al. Proc Natl Acad Sci U S A. 2023.
GSE182582	Mouse	Corneal epithelium	Dry eye	scRNA-seq	33885	Dry eye disease in mice activates adaptive corneal epithelial regeneration distinct from constitutive renewal in homeostasis Lin JB et al. Proc Natl Acad Sci U S A. 2023.
GSE218123	Human	Whole cornea	Normal tissue	scRNA-seq	27423	Single cell RNA-seq of human cornea organoids identifies cell fates of a developing immature cornea Maiti G et al. PNAS Nexus. 2022.
GSE218123	Human	hiPSC-derived corneal organoid	Organoid	scRNA-seq	27153	Single cell RNA-seq of human cornea organoids identifies cell fates of a developing immature cornea Maiti G et al. PNAS Nexus. 2022.
GSE155683	Human	Whole cornea	Keratoconus	scRNA-seq	23984	A single cell atlas of human cornea that defines its development, limbal progenitor cells and their interactions with the immune cells Collin J et al. Ocul Surf. 2021.
GSE155683	Human	Whole cornea	Development	scRNA-seq	124180	A single cell atlas of human cornea that defines its development, limbal progenitor cells and their interactions with the immune cells Collin J et al. Ocul Surf. 2021.
GSE285349	Mouse	Corneal epithelium	Wound healing	scRNA-seq	74851	Single-cell multiomics analysis of early wound response programs in the mouse corneal epithelium Lu ZJ et al. Invest Ophthalmol Vis Sci. 2025.
GSE275678	Mouse	Whole cornea	Wound healing	scRNA-seq	12886	IFITM1/OVOL1 axis is a novel regulator of the expansion of the limbal epithelial stem/early transient amplifying cell population Jiang H et al. FASEB J. 2025.
GSE277598	Mouse	Whole cornea	Wound healing	scRNA-seq	61483	IFITM1/OVOL1 axis is a novel regulator of the expansion of the limbal epithelial stem/early transient amplifying cell population Jiang H et al. FASEB J. 2025.

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