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CorneaMD: A Multiomics Database for Corneal Diseases

Species
Human
Mouse
Macaca fascicularis
Sources
hESC-derived SEAM
Limbus
Limbal epithelium
Limbal stem cells
Whole cornea
Corneal epithelium
Central cornea
Corneal endothelium
hiPSC-derived corneal organoid
Corneal immune cells
hiPSC-derived SEAM
Conditions
Organoid
Normal tissue
Development_10pcw
Development_12pcw
Development_14pcw
Development_16pcw
Development_17pcw
Development_20pcw
Development_Adult
Beclin1-deficient mouse
Keratoconus
Aging
Diabetic keratopathy
Dry eye
Development
Wound healing
Cataract
Technology
scRNA-seq
snRNA-seq
Datasets Species Sources Conditions Technology Cell number Publications
GSE155683 Human Whole cornea Development_Adult scRNA-seq 21343
A single cell atlas of human cornea that defines its development, limbal progenitor cells and their interactions with the immune cells
Collin J et al. Ocul Surf. 2021.
GSE155683 Human Whole cornea Normal tissue scRNA-seq 32548
A single cell atlas of human cornea that defines its development, limbal progenitor cells and their interactions with the immune cells
Collin J et al. Ocul Surf. 2021.
GSE155683 Human Whole cornea Normal tissue scRNA-seq 40675
A single cell atlas of human cornea that defines its development, limbal progenitor cells and their interactions with the immune cells
Collin J et al. Ocul Surf. 2021.
GSE167992 Mouse Limbus Normal tissue scRNA-seq 4738
Discrete limbal epithelial stem cell populations mediate corneal homeostasis and wound healing
Altshuler A et al. Cell Stem Cell. 2021.
GSE158454 Mouse Corneal epithelium Beclin1-deficient mouse scRNA-seq 5499
Single-cell RNA transcriptome helps define the limbal/corneal epithelial stem/early transit amplifying cells and how autophagy affects this population
Kaplan N et al. Invest Ophthalmol Vis Sci. 2019.
GSE158454 Mouse Corneal epithelium Normal tissue scRNA-seq 1370
Single-cell RNA transcriptome helps define the limbal/corneal epithelial stem/early transit amplifying cells and how autophagy affects this population
Kaplan N et al. Invest Ophthalmol Vis Sci. 2019.
GSE158454 Mouse Whole cornea Normal tissue scRNA-seq 2513
Single-cell RNA transcriptome helps define the limbal/corneal epithelial stem/early transit amplifying cells and how autophagy affects this population
Kaplan N et al. Invest Ophthalmol Vis Sci. 2019.
GSE199013 Human Whole cornea Normal tissue snRNA-seq 37478
Cell atlas of the human ocular anterior segment: Tissue-specific and shared cell types
van Zyl T et al. Proc Natl Acad Sci U S A. 2022.
GSE199013 Human Limbus Normal tissue snRNA-seq 51305
Cell atlas of the human ocular anterior segment: Tissue-specific and shared cell types
van Zyl T et al. Proc Natl Acad Sci U S A. 2022.
GSE199013 Human Corneal epithelium Normal tissue snRNA-seq 10330
Cell atlas of the human ocular anterior segment: Tissue-specific and shared cell types
van Zyl T et al. Proc Natl Acad Sci U S A. 2022.
GSE147979 Human Whole cornea Normal tissue snRNA-seq 11023
Multi-species single-cell transcriptomic analysis of ocular compartment regulons
Gautam P et al. Nat Commun. 2021.
HRA000728 Human Central cornea Keratoconus scRNA-seq 39214
Single-cell atlas of keratoconus corneas revealed aberrant transcriptional signatures and implicated mechanical stretch as a trigger for keratoconus pathogenesis
Dou S et al. Cell Discov. 2022.