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CorneaMD: A Multiomics Database for Corneal Diseases

Species
Human
Rabbit
Mouse
Danio rerio
Sources
Corneal endothelium
Central cornea
Corneal epithelium
Whole cornea
Limbal stem cells
Limbus
hiPSC-derived limbal epithelial progenitor cells
Sclera
Corneal stroma
Trigeminal ganglia
Corneal grafts
hESC-derived corneal endothelial cells
Corneal endothelial cells
Mesenchyaml stromal cells
Mesenchymal stromal cells
Tissue-engineered human cornea
Cornea epithelial and stromal cells
Corneal epithelial cells
Conditions
Fuchs' endothelial corneal dystrophy
Keratoconus
Wound healing
Dry eye
Cultured cell lines
SARS-CoV-2 infection
Diabetic keratopathy
Corneal transplantation
Development
Alkali burn
Infectious keratitis
Normal tissue
Bioengineered cornea
Corneal preservation
Technology
Total RNA-seq
mRNA-seq
miRNA-seq
MicroArray
Datasets Species Sources Conditions Technology Sample number Publications
GSE56421 Human Corneal epithelium Corneal transplantation MicroArray 6
Comparative transcriptomic analysis of cultivated limbal epithelium and donor corneal tissue reveals altered wound healing gene expression
Gallagher C et al.Invest Ophthalmol Vis Sci. 2014.
GSE58291 Human Central cornea Infectious keratitis MicroArray 33
Transcriptome data for bacterial and fungal keratitis compared to cadaver cornea
-
GSE74123 Human Corneal endothelium Fuchs' endothelial corneal dystrophy MicroArray 8
Identification of circulating fibrocytes and dendritic derivatives in corneal endothelium of patients with fuchs' dystrophy
De Roo AK et al. Invest Ophthalmol Vis Sci. 2017.
GSE75336 Human Tissue-engineered human cornea Wound healing MicroArray 11
The tissue-engineered human cornea as a model to study expression of matrix metalloproteinases during corneal wound healing
Couture C et al. Biomaterials. 2016.
GSE86584 Human Cornea epithelial and stromal cells Bioengineered cornea MicroArray 6
Successful development and clinical translation of a novel anterior lamellar artificial cornea
Rico-Sánchez L et al. J Tissue Eng Regen Med. 2019.
GSE112039 Human Corneal endothelial cells Fuchs' endothelial corneal dystrophy MicroArray 12
Function-related protein expression in Fuch's endothelial corneal dystrophy cells and tissue models
Thériault M et al.Am J Pathol. 2018.
GSE171830 Human Corneal endothelium Fuchs' endothelial corneal dystrophy MicroArray 6
Differential gene expression analysis of corneal endothelium indicates involvement of phagocytic activity in Fuchs' endothelial corneal dystrophy
Kuot A et al. Exp Eye Res. 2021.
GSE183599 Human Corneal epithelial cells Wound healing MicroArray 5
The WNK1 kinase regulates the stability of transcription factors during wound healing of human corneal epithelial cells
Desjardins P et al. J Cell Physiol. 2022.
GSE185459 Human Corneal epithelial cells Corneal preservation MicroArray 16
Influence of the postmortem/storage time of human corneas on the properties of cultured limbal epithelial cells
Le-Bel G et al. Cells. 2022.
GSE38190 Human Whole cornea Normal tissue MicroArray 11
Preferential biological processes in the human limbus by differential gene profiling
Nakatsu MN et al. PLoS One. 2013.