CorneaMD

CorneaMD: A Multiomics Database for Corneal Diseases

Species
Human
Rabbit
Mouse
Danio rerio

Sources
Corneal endothelium
Central cornea
Corneal epithelium
Whole cornea
Limbal stem cells
Limbus
hiPSC-derived limbal epithelial progenitor cells
Sclera
Corneal stroma
Trigeminal ganglia
Corneal grafts
hESC-derived corneal endothelial cells
Corneal endothelial cells
Mesenchyaml stromal cells
Mesenchymal stromal cells
Tissue-engineered human cornea
Cornea epithelial and stromal cells
Corneal epithelial cells

Conditions
Fuchs' endothelial corneal dystrophy
Keratoconus
Wound healing
Dry eye
Cultured cell lines
SARS-CoV-2 infection
Diabetic keratopathy
Corneal transplantation
Development
Alkali burn
Infectious keratitis
Normal tissue
Bioengineered cornea
Corneal preservation

Technology
Total RNA-seq
mRNA-seq
miRNA-seq
MicroArray

Datasets	Species	Sources	Conditions	Technology	Sample number	Publications
GSE65991	Human	Corneal endothelial cells	Cultured cell lines	mRNA-seq	15	Transcriptomic analysis of cultured corneal endothelial cells as a validation for their use in cell replacement therapy Frausto RF et al. Cell Transplant. 2016.
GSE150008	Mouse	Mesenchyaml stromal cells	Corneal transplantation	mRNA-seq	6	TGF-β1-licensed murine MSCs show superior therapeutic efficacy in modulating corneal allograft immune rejection in vivo Lynch K et al. Mol Ther. 2020.
GSE110872	Human	Corneal endothelial cells	Cultured cell lines	mRNA-seq	8	Comparative transcriptome analysis of hESC- and iPSC-derived corneal endothelial cells Ali M et al. Exp Eye Res. 2018.
GSE81474	Human	Corneal endothelial cells	Cultured cell lines	mRNA-seq	6	Directed differentiation of human embryonic stem cells to corneal endothelial cell-like cells: a transcriptomic analysis Song Q et al. Exp Eye Res. 2016.
GSE121044	Mouse	Whole cornea	Development	mRNA-seq	9	Transformation of the transcriptomic profile of mouse periocular mesenchyme during formation of the embryonic cornea Ma J et al. Invest Ophthalmol Vis Sci. 2019.
GSE41616	Human	Corneal endothelium	Development	mRNA-seq	5	Identification of novel molecular markers through transcriptomic analysis in human fetal and adult corneal endothelial cells Chen Y et al. Hum Mol Genet. 2013.
GSE89537	Mouse	Whole cornea	Alkali burn	mRNA-seq	6	Transcriptome profiling of neovascularized corneas reveals miR-204 as a multi-target biotherapy deliverable by rAAVs Lu Y et al. Mol Ther Nucleic Acids. 2018.
GSE64843	Human	Whole cornea	Infectious keratitis	miRNA-seq	2	Human corneal microrna expression profile in fungal keratitis Boomiraj H et al. Invest Ophthalmol Vis Sci. 2015.
GSE180493	Mouse	Corneal epithelium	Diabetic keratopathy	miRNA-seq	6	Transcriptional network analysis reveals the role of miR-223-5p during diabetic corneal epithelial regeneration Zhang Y et al. Front Mol Biosci. 2021.
GSE113787	Mouse	Whole cornea	Corneal transplantation	miRNA-seq	9	An integrated deep sequencing analysis of microRNAs in transplanted corneas Lu X et al. Mol Immunol. 2018.
GSE166585	Mouse	Mesenchymal stromal cells	Dry eye	miRNA-seq	6	miR-204-containing exosomes ameliorate GVHD-associated dry eye disease Zhou T et al. Sci Adv. 2022.
E-GEOD-81254	Human	Whole cornea	Normal tissue	miRNA-seq	21	miRNA profile in three different normal human ocular tissues by miRNA-Seq Drewry M et al. Invest Ophthalmol Vis Sci. 2016.