CorneaMD

CorneaMD: A Multiomics Database for Corneal Diseases

Species
Human
Rabbit
Mouse
Danio rerio

Sources
Corneal endothelium
Central cornea
Corneal epithelium
Whole cornea
Limbal stem cells
Limbus
hiPSC-derived limbal epithelial progenitor cells
Sclera
Corneal stroma
Trigeminal ganglia
Corneal grafts
hESC-derived corneal endothelial cells
Corneal endothelial cells
Mesenchyaml stromal cells
Mesenchymal stromal cells
Tissue-engineered human cornea
Cornea epithelial and stromal cells
Corneal epithelial cells

Conditions
Fuchs' endothelial corneal dystrophy
Keratoconus
Wound healing
Dry eye
Cultured cell lines
SARS-CoV-2 infection
Diabetic keratopathy
Corneal transplantation
Development
Alkali burn
Infectious keratitis
Normal tissue
Bioengineered cornea
Corneal preservation

Technology
Total RNA-seq
mRNA-seq
miRNA-seq
MicroArray

Datasets	Species	Sources	Conditions	Technology	Sample number	Publications
GSE164073	Human	Limbus	SARS-CoV-2 infection	Total RNA-seq	6	SARS-CoV-2 infects human adult donor eyes and hESC-derived ocular epithelium Eriksen AZ et al. Cell Stem Cell. 2021.
GSE164073	Human	Sclera	SARS-CoV-2 infection	Total RNA-seq	6	SARS-CoV-2 infects human adult donor eyes and hESC-derived ocular epithelium Eriksen AZ et al. Cell Stem Cell. 2021.
GSE142636	Human	Corneal endothelium	Fuchs' endothelial corneal dystrophy	Total RNA-seq	6	Energy shortage in human and mouse models of SLC4A11-associated corneal endothelial dystrophies Zhang W et al. Invest Ophthalmol Vis Sci. 2020.
GSE142635	Mouse	Corneal endothelium	Fuchs' endothelial corneal dystrophy	Total RNA-seq	12	Energy shortage in human and mouse models of SLC4A11-associated corneal endothelial dystrophies Zhang W et al. Invest Ophthalmol Vis Sci. 2020.
GSE112201	Human	Corneal endothelium	Fuchs' endothelial corneal dystrophy	mRNA-seq	28	Gene expression in the corneal endothelium of Fuch's endothelial corneal dystrophy patients with and without expansion of a trinucleotide repeat in TCF4 Wieben ED et al. PLoS One. 2018.
GSE101872	Human	Corneal endothelium	Fuchs' endothelial corneal dystrophy	mRNA-seq	7	Incorporating differential gene expression analysis with predictive biomarkers to identify novel therapeutic drugs for Fuch's endothelial corneal dystrophy Wen H et al. J Ophthalmol. 2021.
GSE180490	Mouse	Corneal epithelium	Diabetic keratopathy	mRNA-seq	6	Transcriptional network analysis reveals the role of miR-223-5p during diabetic corneal epithelial regeneration Zhang Y et al. Front Mol Biosci. 2021.
GSE115355	Mouse	Corneal epithelium	Wound healing	mRNA-seq	16	Molecular basis of Mitomycin C enhanced corneal sensory nerve repair after debridement wounding Stepp MA et al. Sci Rep. 2018.
GSE115355	Mouse	Corneal stroma	Wound healing	mRNA-seq	16	Molecular basis of Mitomycin C enhanced corneal sensory nerve repair after debridement wounding Stepp MA et al. Sci Rep. 2018.
GSE138685	Mouse	Trigeminal ganglia	Wound healing	mRNA-seq	15	Novel RvD6 stereoisomer induces corneal nerve regeneration and wound healing post-injury by modulating trigeminal transcriptomic signature Pham TL et al. Sci Rep. 2020.
GSE181893	Mouse	Corneal grafts	Corneal transplantation	mRNA-seq	6	Anti-CD80/86 antibodies inhibit inflammatory reaction and improve graft survival in a high-risk murine corneal transplantation rejection model Zhu J et al. Sci Rep. 2022.
GSE173692	Human	hESC-derived corneal endothelial cells	Corneal transplantation	mRNA-seq	6	Pluripotent stem cell-derived corneal endothelial cells as an alternative to donor corneal endothelium in keratoplasty Ali M et al. Stem Cell Reports. 2021.